"Topoisomerase targeting by polyphenols: the small ridge between chemoprevention and application-limiting toxicity."

Topoisomerases are crucial enzymes in the maintenance of DNA-topology and integrity. Proliferating cells and cells with high metabolic rate are known to express comparably high levels of topoisomerases, thus representing a well established target for chemotherapy. But topoisomerase-targeting is not limited to chemotherapeutics. So far, multiple polyphenols out of different structural classes have been identified to interfere with topoisomerases, with genistein, resveratrol or delphinidin as prominent representative. The lecture will provide an overview about the potency of polyphenols to target topoisomerases, the consequences for DNA integrity and highlight the question on the combinatory effects of polyphenols and chemotherapeutics.

Die Veranstaltung findet am 15. Mai um 17.00 Uhr in der Nußallee 17 (Geodäsie, Hörsaal XVII) in Bonn-Poppelsdorf statt. Nach dem Vortrag und der Diskussion sind sie herzlich zu einem gemeinsamen Austausch eingeladen.

Weitere Informationen zu Frau Prof. Marko finden Sie hier.