Stefanie Fruhwürth, PhD, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden, will talk about
"How the central nervous system interacts with the periphery to control whole body metabolism.”
Abstract: Obesity has become a worldwide health problem, but we still do not understand the molecular mechanisms that contribute to overeating and low expenditure of energy. Why has controlling food intake become so difficult? There is a complex cross-talk between the central nervous system and the periphery to regulate appetite and food intake to control whole body metabolism. The hormone leptin has emerged as a major regulator of energy balance through its actions in the hypothalamus. Importantly, obese people exhibit high circulating levels of leptin, yet the hypothalamus no longer responds normally to this hormone to suppress appetite or to increase energy expenditure. Several hypotheses have been proposed to explain impaired responsiveness to leptin in obesity, including defective transit across the blood–brain barrier at the arcuate nucleus, hypothalamic endoplasmic reticulum stress, and inflammation in the hypothalamus. We provide a new explanation that is based on our group’s recent discovery of a signaling pathway that we named “NSAPP" after its five main protein components.
Date & Time: Monday, March 25, 2019, 5.00-5.45 pm
Seminarroom U1.023, Endenicher Allee 19b, Bonn-Poppelsdorf
The talk will be followed by an informal Get-together.