The chronic consumption of Western-type calorically rich diets combined with a sedentary lifestyle in Western societies evokes a state of chronic metabolic inflammation, termed metaflammation, and is ‘memorized’ by innate immune cells through long-lasting metabolic and epigenetic cellular reprogramming. Overall, metaflammation contributes to the development of many prevalent non-communicable diseases (f.e. type 2 diabetes, atherosclerosis, cardiovascular diseases, neuro-cognitive diseases and certain cancers), and these lifestyle-associated pathologies represent a rising public health problem with global epidemic dimensions. A better understanding of how modern lifestyle and Western diet activate immune cells is essential for the development of efficient preventive as well as therapeutic strategies for common NCDs. In our Institute, we are assessing the systemic and cellular mechanisms that are activated/ involved in Western lifestyle induced metaflammation. Moreover, we are figuring out how this knowledge can be translated to protect the public from the health burden associated with their selected lifestyle.
Datum und Uhrzeit: Montag, 3. Dezember 2018, 17:00 Uhr
Ort: Seminarraum U1.024, Endenicher Allee 19b, Bonn-Poppelsdorf
Der Vortrag findet in englischer Sprache statt.